Volpe (Wolpe) Itzhak (b. 16 July 1884, Šiauliai, Kovno Governorate) – doctor and public figure.

Itzhak Volpe graduated from the Faculty of Medicine at the University of Vienna. In 1900, he settled in Smolensk, where he became actively involved in pharmaceutical, medical, and public work. He authored numerous medical research papers and was elected a member of the Therapeutic Society affiliated with Moscow University. He presented papers at congresses of Russian therapists. During the war, he served as a military doctor.

After settling in Riga, he continued his active involvement in both medical and public spheres. He served as Chairman of the Jewish War Invalids’ Society, President of the Jewish Theatre Guarantors' Society, and was a member of the presidium of the scientific section of the Latvian Society of Sickness Fund Doctors.